mike carey

Let me think about that, I'd have to leave tomorrow, and DC -10 degrees, Canberra +25 or 30? Yeah, nah.

Let me think about that, I'd have to leave tomorrow, and DC -10 degrees, Canberra +25 or 30? Yeah, nah.

Let me think about that, I'd have to leave tomorrow, and DC -10 degrees, Canberra +25 or 30? Yeah, nah.

Let me think about that, I'd have to leave tomorrow, and DC -10 degrees, Canberra +25 or 30? Yeah, nah.

Shut up you Aussie whiner. Get on your flying kangaroo and come over.

In such cases my tip would be automatically larger yet further away.

seen at a local Thai place......

Just to keep some balance in my life, I also love assuming the bottom position in my extra- curricular activities involving escorts where I am the volunteer with some hired help. 

I wonder how often a stallion at one of these fairs finds himself to be TOO well-endowed for the mares present. Or would such an equine be more of a unicorn? 🤣

Not to mention access to Centurion Lounges at major airports; although some get awfully crowded. 

Scientists in Switzerland have announced the discovery of a new class of antibiotics shown to be effective against deadly, drug-resistant bacteria.
The antibiotic, called zosurabalpin, works by blocking a bacterial molecule called lipopolysaccharide (LPS), which is responsible for creating the outer membrane that protects a harmful bacteria, Acinetobacter baumannii.
Acinetobacter is a “gram-negative” bacteria, which means it is resistant to most antibiotics and other drugs.
It can cause infections in the blood, lungs, urinary tract and other parts of the body, according to the Centers for Disease Control and Prevention (CDC).
In animal studies, zosurabalpin successfully killed drug-resistant strains of Acinetobacter.
The research, conducted at Roche Pharma Research & Early Development in Switzerland, was published in the journal Nature on Jan. 3.
“This new class of antibiotics prevents bacteria from creating their outer membrane, which provide structure to the bacteria and help them survive in harsh environments and cause infection,” Kenneth Bradley, the Switzerland-based global head of infectious disease discovery at Roche, told Fox News Digital via email.
Without the ability to transport LPS — the bacteria die.
“The new molecule overcomes the existing drug-resistance mechanisms that the currently available antibiotics are failing to address,” Bradley said.
This is the first time in over 50 years that a new class of antibiotic has been identified to treat infections by gram-negative bacteria, he noted.
Zosurabalpin specifically targets Acinetobacter.
“The specificity of zosurabalpin is due to the unique way in which it binds to the drug target in these bacteria,” Bradley said.
“Discovery of the mode of action of zosurabalpin in Acinetobacter may enable the identification of other drugs that work in the same way in other antibiotic-resistant bacteria,” Bradley said.
The finding is especially significant, given that resistance to antibiotics has been on the rise in various gram-negative bacteria for several decades, he said.
“Any new antibiotic class that has the ability to treat infections caused by multi-drug-resistant bacteria such as carbapenem-resistant Acinetobacter baumannii (CRAB) would be a significant breakthrough,” he added.
Michael Lobritz, the Switzerland-based head of infectious diseases at Roche, referred in a press release to antimicrobial resistance as a “silent pandemic.”
“Over the next 30 years, it is projected to claim more lives than those taken by cancer today, according to the report of the economist Jim O’Neill,” Lobritz said.
Dr. Marc Siegel, clinical professor of medicine at NYU Langone Medical Center and a Fox News medical contributor, agreed that the growing resistance of gram-negative bacteria is a “huge problem.”
“Our last line of defense for decades now in the hospital has been the carbapenem drugs, specifically Imipenem and Mirapenem,” he told Fox News Digital.
“But now there is an increase of carbapenem-resistant strains — including carbapenem-resistant Acinobacter baumannii, or CRAB — which are very difficult to treat.”
Siegel also acknowledged the importance of the newly discovered zosurabalpin.
“It interferes with a lipid transport mechanism at the surface of the bacteria,” he said. “This is very important, as there are now millions of deaths a year worldwide due to antibiotic resistance.”
Zosurabalpin has only been tested in animals so far, Siegel noted, with human trials underway.
Acinetobacter infections are most commonly seen in hospital patients, mainly affecting those who are on ventilators, have surgical wounds, are in intensive care units or have catheters, according to the CDC.
Those with lung disease, diabetes or weakened immune systems are at a higher risk of infection.
The bacteria can spread from person to person or via contact with contaminated surfaces.
Acinetobacter baumannii, along with other gram-negative bacteria, is tracked by the CDC as part of its Emerging Infections Program.
Looking ahead, Siegel said he expects that artificial intelligence will help speed up the process of developing new antibiotics and make it “more effective and streamlined.
Zosurabalpin is currently in a phase 1 clinical trial, which will evaluate the “safety, tolerability and pharmacokinetics” of the molecule, according to the researcher.
“These data, as well as data from future pivotal phase 3 clinical studies, would be needed to determine the safety and efficacy profile of the molecule,” he added.
The discovery of zosurabalpin, which Bradley calls a “scientific breakthrough,” will help researchers learn more about the construction of bacterial membranes, knowledge that could enable new drugs to kill bacteria.
The hope is that this finding could help eventually to fight other drug-resistant bacteria.
https://nypost.com/2024/01/06/lifestyle/new-antibiotic-kills-deadly-drug-resistant-bacteria-in-scientific-breakthrough/

You give no indication of when you audited these classes, but apparently it was in the past. I'm talking of the future and the present. As I said, "the majority of this current generation who are ready to enter college or currently attending college". 
What you saw in the past has nothing to do with what I'm talking about today.

Queensland (state in Australia) or Queenstown (town on the South Island NZ)?

For a momentary tangent, if you want to chalk up airline experiences and Emirates A380 first class is one of them, they operate Sydney to Christchurch as an add-on to one of their Sydney flights. It's only three hours so not the full EK long haul first class experience, but you can book the two fifth-freedom sectors for cash as either an EK fight or as a Qantas code-share. If you have miles with an airline program that offers you reward flights on Emirates you may be able to find seats there. Qantas FF members can also book reward seats via the QF web site. Despite QF selling the sectors for cash on a QF flight number, they may only show up in reward searches as EK, so if your airline partners with QF but not EK you may not be able to find reward seats.

OMAAT is reporting that Qantas will confirm its order for the long awaited Project Sunrise aircraft today (Monday). When they posted the article on-line an Airbus A350-1000 was en route from Toulouse to Perth, apparently for the announcement. They report that Qantas will order 12 A350-1000s, with 270 seats in four classes of service, to be in service in 2025. At present Qantas only has first class in their A-380s, having retired the B747 before the pandemic. A new first class product will no doubt thrill all the aviation and airline mile collecting anoraks out there. For those of us for whom long haul first is more a theoretical than a practical possibility, they will have a 34" seat pitch in economy, which is pretty good.
Project Sunrise is the Qantas plan to be able to fly non-stop from Sydney and Melbourne to London and New York. Other destinations have been foreshadowed.
OMAAT expect Qantas to also announce firm orders for A320 family aircraft and A220s that will replace their existing fleet of B737 and B717 aircraft for domestic and some short haul international routes. A preliminary announcement of that purchase was made last year.
https://onemileatatime.com/news/qantas-airbus-a350/
 

the ad has never been gone......these app-style links that some forum members use never work......
https://rentmen.eu/JoshKosh
 

WilliamM - There is perhaps (?) some reason for your reposting older posts (4 or 5 years), but I really don't get you're doing so with ones that were posted less than a week ago.😶😥

This video popped in my head and I'm glad it's still around. This is an all time classic! There are higher quality versions on YouTube but I wanted to find one without the age verification wall.
 

gee, to be honest, I liked this thread when it was just about the animals!.......we have a whole "Gallery" for the other stuff!!
 

Indeed they are, but @BSR was not comparing them to each other, he was comparing them with each other. And there are similarities between them.

I’ve never actually had that happen to me. Only once did I feel an escort not wear the appropriate outfit and that was in NYC with a guy who was doing porn for Lucas Entertainment at the time. 
I had met with him previously in  Montreal and we had several dates set up for my trip to NY. It was our first night together and I had told him where we were going, to an upscale restaurant close to my mid town hotel.
He showed up in cut off jeans and a tank top. Of course it showed off his gorgeous physique so I just went with the flow.
At the restaurant the maître d’  placed us at a table discreetly tucked away near the rear with quite subdued lighting.
But we got excellent service with all the male waiters responding to our every request and even unspoken desire. They were especially solicitous to my date. When the time came for the check, they didn’ t bother to ask but just handed it me. 😂

Queenstown

The rankings of the states by amount of debt almost exactly match the rankings by population, so there is nothing really noteworthy there.

The question is not whether we like it or not, but about whether standard etiquette is moving away from phone calls without a heads-up being socially acceptable. I tend not to accept calls from unknown numbers now, but generally will accept them if I know who the caller is. Even then I'll decline if I can't conveniently take the call. Those of us who are in the dinosaur community need to be aware of what current social norms are for calls even if we can ignore them among ourselves!.