Not anymore. The elder of the two died last October, but his younger brother, Harrison Tyler, born in 1928, is still alive.
President John Tyler's grandson, Lyon Gardiner Tyler Jr., dies 175 years after his grandfather left the White House - CNN
President Tyler died in 1862 at 71, when his 13th child (born to his much younger second wife) was nine years old. That son, Lyon Gardiner Tyler, who died in 1935 at 81, also had a much younger second wife and, with her, sons born in the 1920s.