Printers Row, though small, is a nice place to stay. First, it is close to all the public transport (elevated and subway systems, that is). Those will get you to the various neighborhoods and are for the most part near the major bus lines. It has a couple of small hotels and you can get to many of the major museums on foot or take buses or Ls to those that are not within walking distance. You can also walk and see the most noteworthy architectural gems in the City, the Cultural Center, the massive downtown library, and many of the noteworthy theaters. Of course, it is within walking distance of the lake and you can walk or bike along Lakefront. It is just south of the Loop and most of the major businesses. Finally, it is a small neighborhood in its own right and contains shops and restaurants. As the south Loop is being built up, Printers Row is growing along with it.