Getting the latest Covid vaccination

[SirBillybob]

2 hours ago, samhexum said:

I just read this in an article on the stock market today…

A combination Covid-flu vaccination developed by Pfizer Inc. and BioNTech SE missed on one of its goals in a final-stage trial, a setback for the companies as they search for lucrative new uses of a technology that succeeded in the pandemic.

It isn’t clinically or operationally relevant because the investigational COVID formulation component is last year’s. Meanwhile, companies are vying for financial gain and authorization entities stalling on the upcoming season’s needed version engineered for FLiRT variant.

One can always get a separate robust flu vaccine. If the updated COVID vaccine (or prospective combo) were to arrive late to the party then what good would a two-in-one have been anyway, as a window for influenza cases otherwise preventable via timely flu vaccination will have been left ajar?

The study merely began to study proof of concept, and immunogenic potential but not efficacy, at that. 

If all three targets had been each arbitrarily set at 80% desired success, say, the probability of at least one of three failing would be 49%.

Edited August 16 by SirBillybob

[samhexum]

11 minutes ago, SirBillybob said:

It isn’t clinically or operationally relevant because the investigational COVID formulation component is last year’s. Meanwhile, companies are vying for financial gain and authorization entities stalling on the upcoming season’s needed version engineered for FLiRT variant...

You could've just said Big Whoop!  😇😁😊

[marylander1940]

✅ 

[SirBillybob]

34 minutes ago, samhexum said:

You could've just said Big Whoop!  😇😁😊

LOL. I’ve proclaimed that about their Viagra more times than I can recall.

Find my brief allowable expletives on X.

Pfizer and BioNTech will import their whining about profit margins into price gouging. [Restricted expletive]

Edited August 16 by SirBillybob

[Luv2play]

I will be taking a shot in the fall when the new  vaccine is rolled out. Cases are on the rise here in Canada. Heard on CBC yesterday there are 30 deaths a week now in Quebec alone and outbreaks in over 120 long term care facilities. Also over 1000 hospitalizations. 
 

They are expecting numbers to continue rising into the fall. 

[samhexum]

1 hour ago, Luv2play said:

I will be taking a shot in the fall when the new  vaccine is rolled out.

They're due out in the US in a few days and I plan to get one next week,

[SirBillybob]

22 hours ago, Luv2play said:

I will be taking a shot in the fall when the new  vaccine is rolled out. Cases are on the rise here in Canada. Heard on CBC yesterday there are 30 deaths a week now in Quebec alone and outbreaks in over 120 long term care facilities. Also over 1000 hospitalizations. 
 

They are expecting numbers to continue rising into the fall. 

I am getting hot under the collar and it’s not fever. It appears that Health Canada and NACI are dicking around holding out for a viable COVID-Influenza combo vaccination. Yet PfizerBioNTech, Moderna, and Novavax new formulations are all set to go.

My interpretation of the reason for the USA FDA’s continuing review of Novavax’ submission is that the just approved mRNA monovalent doses target KP.2 strain specifically while Novavax targets the parent strain JN.1 strain and the company asserts cross-reactivity with KP.2 strain. 

I was at Montréal’s downtown vaxx centre yesterday and the nurses thought November for any product rollout. Impossible, I hope. Canada had better uncouple vaccination for the two diseases this Fall. 

Again, makes my blood boil. This year is just a repeat of last year’s delay to October-ish. There are sufficient data precedents. 

Edited August 24 by SirBillybob

[misterhumphries]

I have gotten every Covid vaccination on offer and I plan to get the next one as soon as it's offered. I've had a mild case of Covid. Worst time in my life! The pity is people don't take it seriously any more.. it really is WORSE than the worst cold.

[+ Pensant]

15 hours ago, misterhumphries said:

The pity is people don't take it seriously any more

I wonder why that is?

[+ FrankR]

16 hours ago, misterhumphries said:

I have gotten every Covid vaccination on offer and I plan to get the next one as soon as it's offered. I've had a mild case of Covid. Worst time in my life! The pity is people don't take it seriously any more.. it really is WORSE than the worst cold.

USA Today ran an article on seasonal vaccines today. The updated Pfizer and Moderna vaccines are now available. They specifically mentioned CVS and Walgreens are taking appointments. No sign yet of the promised Covid & Flu combination vaccine. So will need two jabs again. 

[+ Charlie]

The newest vaccines didn't become available in time for me. On Tuesday I woke with a high fever and headache, and when I self-tested, I was positive. I immediately went out and bought another test from a different company, but the result was the same. I was thankful that I managed to move my spouse into an assisted living facility a week ago, because I don't know how I could have taken care of him or avoided giving the virus to him. At least now when he asks why I think he should be in assisted living, I have a strong response to give to him, but I'm not allowed in to see him right now.

Strangely, most of the gay men who live on my street also have COVID right now, but none of the straight people do (at least, as far as I know).

[misterhumphries]

9 hours ago, Pensant said:

I wonder why that is?

Because the nation is more entitled, more selfish, more self-centered than any previous generation in American history. Can you imagine the specimens we have around us weaned on Instagram, Facebook, etc trying to live with WW II deprivations such as rationing, volunteerism? Putting the good of our neighbors over our petty immediate desires? People moaned and rationalized ad nauseam about Covid. People hoarded food, toilet tissue; anything they could get their hot little hands on as if the world were ending. Now that restrictions are lifted, no one will willingly give anything Covid-related any credence because that would be admitting they were wrong. Never mind the millions who died from its complications.

Edited August 29 by misterhumphries

[misterhumphries]

7 hours ago, Charlie said:

......Strangely, most of the gay men who live on my street also have COVID right now, but none of the straight people do (at least, as far as I know).

Let's not try to even hint there is a correlation between Covid susceptibility and sexual identity. A virus doesn't care who you fuck or how you do it.

[mike carey]

2 hours ago, misterhumphries said:

Let's not try to even hint there is a correlation between Covid susceptibility and sexual identity. A virus doesn't care who you fuck or how you do it.

I think I know @Charlie well enough to be sure that he had not drawn any such inference from his observation. 'Most of the gay men in my street' is a group who are likely to have socialised (coincidentally) at a time when at least one of them was infectious. Maybe at one time, or maybe serial infections. None of them happened to socialise with any of the straight people? Gosh, how could that happen?

[RadioRob]

I received both my flu and updated covid shot yesterday at my local CVS in Wilton Manors.  I was in and out in 10 minutes and have a $5 off CVS coupon to boot.

No issues outside of the normal soreness at the injection site.  I rolled over in the middle of the night and rolled right back over a second later when my arm said "NOPE!  Not tonight... Not in the mood honey."

[+ Charlie]

1 hour ago, mike carey said:

I think I know @Charlie well enough to be sure that he had not drawn any such inference from his observation. 'Most of the gay men in my street' is a group who are likely to have socialised (coincidentally) at a time when at least one of them was infectious. Maybe at one time, or maybe serial infections. None of them happened to socialise with any of the straight people? Gosh, how could that happen?

Actually, I socialize much more with the straight neighbor couple from whom I learned that one of the gay couples has COVID (I don't socialize with them at all, and I haven't seen the other gay couple who admit to having COVID in more than a month). I also wasn't implying that gay men are more susceptible to COVID than straight people, just that it seemed surprising that the only neighbors on the block that are known to have COVID right now all happen to be gay men. During the pandemic, the only neighbors I knew who had COVID were all straight.

[+ Vegas_Millennial]

6 hours ago, misterhumphries said:

...A virus doesn't care who you fuck or how you do it.

I had personal success only doing it Doggie style during the height of pandemic... Keeping our mouths six feet apart.

I suspect those who did it Missionary were more susceptible to the virus spread.

[SirBillybob]

5 hours ago, Vegas_Millennial said:

I had personal success only doing it Doggie style during the height of pandemic... Keeping our mouths six feet apart.

I suspect those who did it Missionary were more susceptible to the virus spread.

In which case you or he more than likely were vigorously sloshing around and spraying fine queefy droplet mists of contaminants up into your face ping-pong stage show-grade that otherwise would have eventually ended up in wastewater pathogen surveillance lab test tubes. The average doggie knows there’s no bargaining with a virus or worm. Pass him the hazmat suit either side of the glory hole.

Edited August 30 by SirBillybob

[+ poolboy48220]

8 hours ago, RadioRob said:

I received both my flu and updated covid shot yesterday at my local CVS in Wilton Manors.  I was in and out in 10 minutes and have a $5 off CVS coupon to boot.

No issues outside of the normal soreness at the injection site.  I rolled over in the middle of the night and rolled right back over a second later when my arm said "NOPE!  Not tonight... Not in the mood honey."

Exactly my experience, including the $5 coupon (got some Haagen-Daaz! 😁) I was going to do my 2nd shingles shot too but the tech advised getting against all three since I'd be really sore.

[+ Pensant]

I hope my luck continues to hold out. I still have not contracted “symptomatic” Covid, and I’m certainly not a hermit.

[hsgual]

I really hope Novovax comes out soon. Some of the data suggests it offers longer protection. The FDA is dragging. 

[pubic_assistance]

On 12/29/2023 at 1:04 PM, Luv2play said:

So far I have avoided getting COVID

Highly unlikely.

What you mean is you've avoided the symptoms of Covid.

It's highly contagious so eventually most everyone was infected at some point. Fortunately  for most healthy individuals their immune system moved quickly to deal with it and they barely knew they were infected. Or in your case they think they were never infected. This is a common misconception. I hear people saying this all the time.

[SirBillybob]

5 hours ago, hsgual said:

I really hope Novovax comes out soon. Some of the data suggests it offers longer protection. The FDA is dragging. 

It’s likely your history is exclusively mRNA uptake: homologous dosing. Mine is heterologous as I’ve had both mRNA and protein subunit formulations, reverse order compared to most. Non-mRNA from the outset. However, I always want to know if there’s a bit of an edge, though don’t get too wrapped up in it, and now possess the added factor of capital H hybrid immunity having caught moderately severe COVID prior to my next upcoming vaccine dose. 

The latest meta-analysis available suggests no benefit either way across key outcomes. Temporality/duration of protection is virtually impossible to compare for logistic reasons.

Novavax’ Nuvaxovid formulations are mostly a subjective preference. My protein subunit intake was associated with bedridden level reaction no less than with Comirnaty or Spikevax. I’m not adamant currently about cross-platform vaccine consumption. I’ll shoulder first one out of the gate. 

I think at this point the FDA (and Health Canada also dragging, etc) review's Nuvaxovid, albeit slowly, and approves it to accommodate mRNA refuseniks, or recipients that may have a true or anticipated contraindication. Products are now reviewed according to preclinical and indirect clinical data with efficacy metrics relatively absent and resting on laurels.

Heterologous versus homologous COVID-19 booster vaccinations for adults: systematic review with meta-analysis and trial sequential analysis of randomised clinical trials | BMC Medicine | Full Text

BMCMEDICINE.BIOMEDCENTRAL.COM

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Background To combat coronavirus disease 2019 (COVID-19), booster vaccination strategies are important...

 

Edited August 30 by SirBillybob

[SirBillybob]

1 hour ago, pubic_assistance said:

Highly unlikely.

What you mean is you've avoided the symptoms of Covid.

It's highly contagious so eventually most everyone was infected at some point. Fortunately  for most healthy individuals their immune system moved quickly to deal with it and they barely knew they were infected. Or in your case they think they were never infected. This is a common misconception. I hear people saying this all the time.

Actually reasonably likely (about 20% across all our regions) no exposure as it would elicit nucleocapsid antibodies. Canada continues statistically representative infection seroprevalence surveillance through an immunity task force. It’s a common misconception that only a small minority have escaped infection. Contagion is but one factor.

I myself did suck and fuck for 40 months with Lady Luck 🍀 hovering but acquired infection with incidence at a nadir.

Edited August 30 by SirBillybob

[SirBillybob]

Ha. Authorized as of today.

Novavax 2024-2025 Formula COVID-19 Vaccine Now Authorized and Recommended for Use in the U.S. - Aug 30, 2024

IR.NOVAVAX.COM

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Novavax expects pre-filled syringes will be broadly available in thousands of locations across the U.S. Novavax's...